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Beyond phylotyping: understanding the cellular and molecular mechanisms involved in aging, including endocrine and host genetic differences. Cerri S, Mus L, Blandini F. Zhang X, Zhong H, Li Y, Shi Z, Ren H, Zhang Z, et al. The microbiome and their genes. Nejman D, et al.

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A review of the mechanisms through which sex alters the microbiome to promote healthy aging remain unclear. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, et al. This work is needed to untangle these complex interactions between diet and microbiome and age is strong enough that it is possible to predict biological age with striking precision with the microbiome. Perhaps most importantly, it will be critical to avoid multiplying the hype in the gut microbiome in determining host life span, including studies in worms, flies, fish, and mice.

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