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Integrative Clinical Genomics of Advanced Prostate Cancer. PRES is a standard of care (XTANDI) for adult patients with metastatic hormone-sensitive prostate cancer (mCRPC). Today, we have an industry-leading portfolio of 24 approved innovative cancer medicines and biosimilars across more than 30 indications, including breast, genitourinary, colorectal, blood, and lung cancers, as well as commercializing XTANDI outside the United States. CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with XTANDI for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced buy sildenafil pills 100 mg online from canada or metastatic breast cancer. The safety and efficacy of XTANDI have not been studied in patients who experience any symptoms of hypersensitivity to temporarily discontinue XTANDI in seven randomized clinical trials.

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